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Title |
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Human Cytokinome: a new challenge for systems biology |
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Authors |
Susan Costantini1, 2*, Giuseppe Castello1, Giovanni Colonna2 |
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Affiliation |
1CROM (Oncology Research Centre of Mercogliano) Fiorentino Lo Vuolo, via Ammiraglio Bianco, 83013 Mercogliano (IT);2Department of Biochemistry and Biophysics and CRISCEB - (Interdepartmental Research Center for Computational and Biotechnological Sciences), Second University of Naples, via Costantinopoli 16, 80138 Naples (IT) |
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+39 0825 1911730 |
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+39 0825 1911705; * Corresponding author |
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Article Type |
Views & Challenges
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Date |
Received June 09 2010; Accepted July 09 2010; Published October 06 2010 |
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Abstract |
Cytokines play an important role in the evolution of inflammatory processes. Therefore, they are also key components of the cancer evolution, a disease recognized to depend on chronic inflammation. On the whole, we define cytokinome as the totality of these proteins and their interactions in and around biological cells. Understanding the complex interaction network of cytokines in patients affected from cancers should be very useful both to follow the cancer evolution from its early steps and to define innovative therapeutic strategies by using systems biology approaches. |
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Keywords
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cytokine; chronic inflammation; cancer; systems biology. |
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Citation |
Costantini et al Bioinformation, 5 (4) 166-167, 2010 |
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Edited by |
P. Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |