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High AU content: a signature of upregulated miRNA in cardiac diseases



Richa Gupta, Neha Soni, Purbasa Patnaik, Ishita Sood, Rahul Singh, Kamal Rawal, Vibha Rani*



Department of Biotechnology, Jaypee Institute of Information Technology University, Noida, U.P-201307, India.

E-mail*;* Corresponding author


Article Type






Received August 5, 2010; accepted August 26, 2010; published September 20, 2010




MicroRNAs have been implicated for the regulation of gene expression. These miRNA are a class of single stranded non coding RNAs, formed from endogenous transcripts and measure typically about 19-25 nucleotides in length. They are important regulators of the various biological and metabolic functions taking place in humans. Many miRNAs show tissue specific expression. Human heart is a complex organ which during various diseased and developed conditions shows differential expression of miRNA. Here, we overview the recent findings on miRNA in cardiac diseases and report the presence of high AU content in differentially expressed miRNA in developed and diseased condition of heart as compared to all the miRNA present in the human. A total of 905 human miRNA sequences taken from miRBase were computationally analyzed. Trend analysis was performed to study the influence of positional frequency of the nucleotides. This study will help us in understanding the significance of AU rich elements in miRNA during the development of cardiac diseases.




Cardiac, miRNAs, Regulation, miRBase, AU content, Bioinformatics




Gupta et al. Bioinformation 5(3): 132-135 (2010)

Edited by


P. Kangueane








Biomedical Informatics




This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.