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Title
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Molecular interactions between Bos taurus interferon-τ1c and human type I interferon receptor
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Authors
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Vishawdeep Singh Jamwal, Gourav Modi, Aman George*, Manmohan Singh Chauhan | |
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Affiliation |
Embryo Biotechnology Lab, Animal Biotechnology Centre, National Dairy Research Institute, Karnal-132001, Haryana, India
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Article Type
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Hypothesis | |
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Date
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Received June 28, 2009; Revised August 17, 2009; Accepted September 11, 2009; Published October 13, 2009 | |
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Abstract |
Interferon (IFN)-τ secreted only by ruminant endometrium, helps in maternal recognition of pregnancy and exhibit antiviral and antiproliferative activity. Among different types of IFN-τ, IFN-τ1c and IFN- τ3a are the most highly expressed isoforms. In the present study structure of INF-τ1c was predicted using homology modelling. The best model was selected based on overall stereo-chemical quality. The generated 3D structure of the Interferon-τ1c protein of Bos taurus was predicted using the ovine interferon-τ (PDB ID: 1B5L_A) as template. The structure comprises of 5 α helices separated by loop regions, which is similar to the one predicted for other IFNs. Molecular interactions of bovine IFN-τ1c with human interferon Type 1 receptor (IFNAR1) was explored in an attempt to predict human IFNAR1 binding sites of IFN-ζ1c.
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Keywords |
interferon; interactions; human interferon receptor; Bos taurus
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Citation
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Jamwal et al., Bioinformation 4(4): 155-157 (2009) | |
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Edited by
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P. Kangueane
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ISSN
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0973-2063
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Publisher
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License
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This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |