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Title

 

 

 

 

 

HNHDb: A database on pattern based classification of HNH domains reveals functional relevance of sequence patterns and domain associations.

 

Authors

 

Alaguraj Veluchamy*, Sujitha Mary, Vishal Acharya, Preeti Mehta, Taru Deva, Sankaran Krishnaswamy

 

Affiliation

 

Center of Excellence in Bioinformatics, School of biotechnology, Madurai Kamaraj University, Madurai, India

 

Email

 

alaguraj@mkustrbioinfo.in

Article Type

 

Database

Date

 

Received June 24, 2009; Accepted July 26, 2009; Published September 06, 2009

Abstract

The HNH Database is a collection and sequence-based classification of HNH domain proteins. The database contains about 1913 HNH domain containing proteins, and is classified into 10 subsets based on the sequence pattern. Each of these subsets has unique signature sequences. We have shown a correlation between the subset combination and their domain association and function. Functional divergence of this domain may be due to the combination of these conserved patterns and the large variations in the non-conserved regions. HNHDb is freely available at http://bicmku.in:8081/hnh.

 

Keywords

 

HNH domains; HNHDb; sequence classification

Citation

 

 Veluchamy et al., Bioinformation 4(2): 80-83 (2009)

Edited by

 

P. Kangueane

 

ISSN

 

0973-2063

 

Publisher

 

Biomedical Informatics

 

License

 

 

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.