Title

Identification and analysis of putative promoter motifs in Flavivirus genome

Authors

 Pallavi Somvanshi^1, *, Vijai Singh² and P. K. Seth¹

Affiliation

¹Bioinformatics Centre, Biotech Park, Lucknow; ²Aquatic Microbes Section, National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow

Email

 psomvanshi@gmail.com; * Corresponding author

Article Type

Hypothesis

Date

received August 07, 2008; revised October 15, 2008; accepted October 30, 2008; published December 06, 2008

Abstract

The genus Flavivirus comprises medically significant pathogenic virus; causing several infections in humans worldwide. Flavivirus genomes are 10-11 kb approximately and encode both structural and non structural region. The non structural region plays fundamental role in the stability, regulation and cell cycle of virus. The complete genomes of 26 Flavivirus were used for identification of promoter motifs through in silico approaches. The promoter sequences were encoded in merely 16 viruses and 10 viruses could not encode it. All these in silico identified promoter motifs was confirmed and verified with the known experimental data. This analysis suggests that presence of promoter may play a crucial role in the pattern of gene expression, regulation networks, cell specificity and development. It may also be useful for designing efficient expression vector and target specific delivery system in the gene therapy.

Keywords

 Flavivirus; disease; promoter; regulation; cell cycle

Citation

 Somvanshi et al., Bioinformation 3(4): 162-167 (2008)

Edited by

P. Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.