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Title

 

 

 

 

Analysis of PB2 protein from H9N2 and H5N1 avian flu virus

 

Authors

Danishuddin1 and Asad Ullah Khan1, 2, *

 

Affiliation

1Bioinformatics distributed Information sub-centre, AMU, Aligarh-202002, India; 2Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh-202002, India

 

Email

huzzi99@hotmail.com; * Corresponding Author

 

Phone

91-571-2723088

 

Fax

91-571-2721776

 

Article Type

Hypothesis

 

Date

received April 26, 2008; revised June 10, 2008; accepted July 06, 2008; published September 22, 2008

 

Abstract

Influenza A viruses of subtype H9N2 are wide spread among poultry and other mammalian species. Crossing the species barrier from poultry to human occurred in recent years creating a pandemic of H9N2 virus. It is known that the pathogenicity of H9N2 is lower than H5N1. Nonetheless, it is important to establish the molecular functions of H9N2 viral proteins. We studied mutations in the polymerase protein PB2 of H9N2 from different strains and compared it with the highly pathogenic H5N1. The mutation M294T was found to be important in the N-myristoylation domain of Ck/UP/2573/India/04(H9N2) isolate. Prediction of secondary structures and PROSITE motif assignments were performed for PB2 to gain functional insight. Subsequently, the effect of mutations in secondary structures among strains is discussed.

 

Keywords

PB2 protein; H5N1; H9N2; Mutations; N-myristoylation domain

 

Citation

Danishuddin & Khan, Bioinformation 3(1): 41-46 (2008)

 

Edited by

P. Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

License

 

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.