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Title |
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Molecular drug targets and structure based drug design: A holistic approach
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Authors |
Shailza Singh 1*, Balwant Kumar Malik 2, Durlabh Kumar Sharma 1
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Affiliation |
1 Center for Energy Studies, Indian Institute of Technology Delhi, Hauz Khas, New Delhi-110016, India; 2 Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi-110007, India
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Phone |
+91-11-26591256
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Fax |
+91-11-26581121; * Corresponding author
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Article Type |
Current Trends
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Date |
received December 11, 2006; revised December 21, 2006; accepted December 23, 2006; published online December 23 , 2006
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Abstract |
Access to the complete human genome sequence as well as to the complete sequences of pathogenic organisms provides information that can result in an avalanche of therapeutic targets. Structure-based design is one of the first techniques to be used in drug design. Structure based design refers specifically to finding and complementing the 3D structure (binding and/or active site) of a target molecule such as a receptor protein. The aim of this review is to give an outline of studies in the field of structure based drug design that has helped in the discovery process of new drugs. The emphasis will be on comparative/homology modeling.
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Keywords
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drug targets; protein modeling; ligands; design
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Citation |
Singh et al., Bioinformation 1(8): 314-320 (2006)
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Edited by |
P. Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |