Title

Modeling of the potential coiled-coil structure of snapin protein and its interaction with SNARE complex
 

Authors

Ragul Gowthaman*, A Johnwin Silvester, Saranya K, Rathna Kanya K.S, Archana N.R

Affiliation

Department of Bioinformatics, School of Chemical and Biotechnology, Shanmugha Arts Science Technology & Research Academy (SASTRA), SASTRA UNIVERSITY, Tanjore, Tamilnadu, India

Email

ragul@bioinfo.sastra.edu;* Corresponding author

Article Type

Hypothesis

Date

received September 20, 2006; revised November 20, 2006; accepted November 27, 2006; published online December 02, 2006

Abstract

Autism is a developmental disability causing learning and memory disorder. The heart of the search for a cure for this syndrome is the need to understand dendrite branch patterning, a process crucial for proper synaptic transmission. Due to the association of snapin with the SNARE complex and its role in synaptic transmission it is reported as a potential drug target for autism therapies. We wish to impart the noesis of the 3D structure of the snapin protein, and in this chase we predict the native structure from its sequence of amino acid residues using the classical Comparative protein structure modeling methods. The predicted protein model can be of great assistance in understanding the structural insights, which is necessary to understand the protein function. Understanding the interactions between snapin and SNARE complex is crucial in studying its role in the neurotransmitter release process. We also presented a computational model that shows the interaction between the snapin and SNAP-25 protein, a part of the larger SNARE complex.

Keywords

snapin; autism; memory; disorder; SNARE complex; modelling

Citation

Edited by

R. Sowdhamini

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.