Title

Binding site prediction of galanin peptide using evolutionary trace method

Authors

Shanthi Nagarajan & Parthiban Marimuthu ^*

Affiliation

Bioinformatics Centre, Pondicherry University, Pondicherry, India;

E-mail*

ma_parthiban@yahoo.co.in; * Corresponding author

Phone

+91 (0413) 2655212

Fax

+91 (0413) 2655211

Article Type

Hypothesis

Date

received June 08, 2006; revised July17, 2006; accepted July 24, 2006; published online July 25, 2006

Abstract

Galanin is a neuropeptide with aminoacid length ranging from 29 to 31 is widely distributed in central and peripheral nervous system. Galanin controls various psychological processes such as sensation of pain, learning, feeding, and sexual behaviour. The N-terminal region of this neuropeptide has highly conserved 15 amino acids, which is triggered by galanin receptors. We performed evolutionary trace analysis for galanin sequences to gather information about functional residues. The consensus pattern given by the evolutionary trace (ET) analysis is supported by CLUSTALW and WEBLOGO results. Our observations strongly suggest the presence of functional residues in the N-terminal region of galanin for agonist-receptor binding.

Keywords

Evolutionary trace; Binding site; Agonist- receptor

Citation

Edited by

R. Sowdhamini

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.